China_Watcher
10-29-2005, 08:55 AM
Chinese are interesting asian stating the first people with uniquely long history (5000 years old). The most common view of chinese origin is that they come from the Yangtze and Yellow river, however the recent scientific evidences suggest that they come from the south east asia, and then expand to the northern parts of china .
Phylogeographic Differentiation of Mitochondrial DNA in Han Chinese
Yong-Gang Yao,1 Qing-Peng Kong,1 Hans-Jürgen Bandelt,2 Toomas Kivisild,3 and Ya-Ping Zhang1
1Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; 2Fachbereich Mathematik, Universität Hamburg, Hamburg; 3Department of Evolutional Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
Received September 20, 2001; accepted for publication December 4, 2001; electronically published February 8, 2002.
To characterize the mitochondrial DNA (mtDNA) variation in Han Chinese from several provinces of China, we have sequenced the two hypervariable segments of the control region and the segment spanning nucleotide positions 1017110659 of the coding region, and we have identified a number of specific coding-region mutations by direct sequencing or restriction-fragmentlengthpolymorphism tests. This allows us to define new haplogroups (clades of the mtDNA phylogeny) and to dissect the Han mtDNA pool on a phylogenetic basis, which is a prerequisite for any fine-grained phylogeographic analysis, the interpretation of ancient mtDNA, or future complete mtDNA sequencing efforts. Some of the haplogroups under study differ considerably in frequencies across different provinces. The southernmost provinces show more pronounced contrasts in their regional Han mtDNA pools than the central and northern provinces. These and other features of the geographical distribution of the mtDNA haplogroups observed in the Han Chinese make an initial Paleolithic colonization from south to north plausible
Phylogeographic Differentiation of Mitochondrial DNA in Han Chinese
Yong-Gang Yao,1 Qing-Peng Kong,1 Hans-Jürgen Bandelt,2 Toomas Kivisild,3 and Ya-Ping Zhang1
1Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; 2Fachbereich Mathematik, Universität Hamburg, Hamburg; 3Department of Evolutional Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
Received September 20, 2001; accepted for publication December 4, 2001; electronically published February 8, 2002.
To characterize the mitochondrial DNA (mtDNA) variation in Han Chinese from several provinces of China, we have sequenced the two hypervariable segments of the control region and the segment spanning nucleotide positions 1017110659 of the coding region, and we have identified a number of specific coding-region mutations by direct sequencing or restriction-fragmentlengthpolymorphism tests. This allows us to define new haplogroups (clades of the mtDNA phylogeny) and to dissect the Han mtDNA pool on a phylogenetic basis, which is a prerequisite for any fine-grained phylogeographic analysis, the interpretation of ancient mtDNA, or future complete mtDNA sequencing efforts. Some of the haplogroups under study differ considerably in frequencies across different provinces. The southernmost provinces show more pronounced contrasts in their regional Han mtDNA pools than the central and northern provinces. These and other features of the geographical distribution of the mtDNA haplogroups observed in the Han Chinese make an initial Paleolithic colonization from south to north plausible